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Inference of the model parameters was performed in the framework of Bayesian inference, wherein random draws of the posterior distribution were obtained using Sequential Monte Carlo (SMC), see Svensson and Schn (2017) and The state space model and posterior model parameter samples were then used to construct posterior predictive distributions of the response of each readout to a given test material for a given concentration and timepoint (see Figure 4)

A.Espitia-RangelE.Rodrguez-ArvaloI.Snchez-SeguraL.Martnez-GallardoN

Proc Natl Acad Sci USA (2008) 105:1942631

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SARS-CoV-2 dysregulation of mitochondrial dynamics produces dysfunctional, hollow, elongated mitochondria with high membrane potential A transcriptomic and metabolomic data analysis of the changes in mitochondrial morphology and function induced by SARS-CoV-2 accessory proteins in A549 human lung carcinoma cells reported the detection of two distinct subpopulations of mitochondria with high and low activity